国产抗人T细胞猪免疫球蛋白导致心脏不良反应及原因探讨

何江华,胡致平*,周郁鸿

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (16) : 1467-1469.

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中国药学杂志 ›› 2014, Vol. 49 ›› Issue (16) : 1467-1469. DOI: 10.11669/cpj.2014.16.022
药物与临床

国产抗人T细胞猪免疫球蛋白导致心脏不良反应及原因探讨

  • 何江华1,胡致平2*,周郁鸿2
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The Cardiac Adverse Events Associated with ATG-P in the Treatment of Severe Aplastic Anemia:Case Report and Literature Review

  • HE Jiang-hua1, HU Zhi-ping2*,ZHOU Yu-hong2
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摘要

目的 观察国产抗人T细胞猪免疫球蛋白(ATG-P)在治疗重型再生障碍性贫血(SAA)过程中的心脏不良反应,探索其可能发生机制,探讨其防治对策。方法 对采用国产抗人T细胞猪免疫球蛋白治疗的3例患者的临床资料进行分析。结果 3例患者均完成ATG-P的治疗,均出现不同表现的心脏不良反应。结论 抗人T细胞猪免疫球蛋白会导致不同的心脏不良反应。在抗人T细胞猪免疫球蛋白治疗中,应注意对心脏不良反应的观测,及时对症处理。

Abstract

OBJECTIVE To observe the cardiac adverse events associated with antithymocyte globulin(ATG) in the treatment of severe aplastic anemia(SAA),and analyze its possible pathogenetic mechanisms and prophylactic measures.METHODS The clinical data of 3 cases with severe aplastic anemia(SAA) who received treatment with ATG-P in our hospital were analyzed retrospectively.RESULTS Three cases finished ATG treatment and developed different cardiacadverse events.CONCLUSION Therapy-related cardiac adverse events occured in some of the patients.It was necessary to pay attention to monitoring the cardiac adverse events when we use ATG-P.

关键词

重型再生障碍性贫血 / 抗人T细胞猪免疫球蛋白 / 心脏不良反应

Key words

severe aplastic anemia / antithymocyte globulin / cardiac adverse event

引用本文

导出引用
何江华,胡致平*,周郁鸿. 国产抗人T细胞猪免疫球蛋白导致心脏不良反应及原因探讨[J]. 中国药学杂志, 2014, 49(16): 1467-1469 https://doi.org/10.11669/cpj.2014.16.022
HE Jiang-hua, HU Zhi-ping*,ZHOU Yu-hong. The Cardiac Adverse Events Associated with ATG-P in the Treatment of Severe Aplastic Anemia:Case Report and Literature Review[J]. Chinese Pharmaceutical Journal, 2014, 49(16): 1467-1469 https://doi.org/10.11669/cpj.2014.16.022
中图分类号: R978.1   

参考文献

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基金

2012年国家中医临床研究基地业务建设科研专项(ZDZX2012173)
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